Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women
A partir des données d'études d'association sur le génome entier, cette étude (5 066 cas et 4 337 témoins) évalue l'association entre 237 polymorphismes de 32 gènes impliqués dans les voies de la biosynthèse des micro-ARNs et le risque de cancer du sein chez des femmes asiatiques
Background:Although the role of microRNA in cancer development and progression has been well established, the association between genetic variants in microRNA biogenesis pathway genes and breast cancer risk has been yet unclear. Methods:We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the SNPs which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in microRNA biogenesis pathway and its regulation. Results:Although 8 SNPs were nominally associated with breast cancer risk in combined samples (P<0.05), none of them were significant after adjustment for multiple comparisons. Conclusions:The common genetic variants in microRNA biogenesis pathway genes may not be associated with breast cancer risk. Impact: This study suggests no association between the polymorphisms in microRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association.