Considerations in the development of circulating tumor cell technology for clinical use
Cet article passe en revue les perspectives offertes par les technologies de détection des cellules tumorales circulantes pour le diagnostic, le pronostic et la prédiction de la réponse thérapeutique
This manuscript summarizes current thinking on the value and promise of evolving circulating tumor cell (CTC) technologies for cancer patient diagnosis, prognosis, and response to therapy, as well as accelerating oncologic drug development. Moving forward requires the application of the classic steps in biomarker developmentanalytical and clinical validation and clinical qualification for specific contexts of use. To that end, this review describes methods for interactive comparisons of proprietary new technologies, clinical trial designs, a clinical validation qualification strategy, and an approach for effectively carrying out this work through a public-private partnership that includes test developers, drug developers, clinical trialists, the US Food & Drug Administration (FDA) and the US National Cancer Institute (NCI).
Journal of Translational Medicine , article en libre accès, 2011