Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma
Menée sur un modèle murin, cette étude met en évidence le rôle joué par Sox10 dans la formation d'un naevus congénital géant et d'un mélanome
Giant congenital naevi are pigmented childhood lesions that frequently lead to melanoma, the most aggressive skin cancer. The mechanisms underlying this malignancy are largely unknown, and there are no effective therapies. Here we describe a mouse model for giant congenital naevi and show that naevi and melanoma prominently express Sox10,…
Nature Cell Biology 2012