Increased Risk of Stomach and Esophageal Malignancies in People with AIDS
A partir des données de 16 registres américains portant sur la période 1980 - 2007, cette étude montre, par rapport à la population générale, un risque élevé de cancers de l'estomac ou de l'œsophage chez les patients atteints d'un SIDA (596 955 patients)
People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk for cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with AIDS. We analyzed data from the HIV/AIDS Cancer Match Study, which links data collected from 1980 to 2007 for 16 US population-based HIV and AIDS and cancer registries. We compared risks of stomach and esophageal malignancies in people with AIDS (n=596,955) with those of the general population using standardized incidence ratios (SIRs). We assessed calendar trends using Poisson regression. People with AIDS had increased risks of carcinomas of the esophagus (SIR=1.69; 95% confidence interval [CI], 1.37–2.07; n=95) and stomach (SIR=1.44; 95% CI, 1.17–1.76; n=96). Risk was increased for esophageal adenocarcinoma (SIR=1.91; 95% CI, 1.31–2.70) and squamous cell carcinoma (SIR=1.47; 95% CI, 1.10–1.92). People with AIDS had greater risks of carcinomas of the gastric cardia (SIR=1.36; 95% CI, 0.83–2.11) and non-cardia (SIR=1.53; 95% CI, 1.12–2.05) than the general population. Though most stomach and esophageal NHLs that developed in people with AIDS were diffuse large B-cell lymphomas, these individuals also had an increased risk of stomach mucosa-associated lymphoid tissue lymphoma (SIR=5.99; 95% CI, 3.19–10.2; n=13). The incidence of carcinomas remained fairly constant over time, but rates of NHL decreased from 1980 to 2007 (Ptrend<.0001). People with AIDS are at increased risk for developing esophageal and stomach carcinomas and NHLs. Although the incidence of NHL decreased from 1980 to 2007, as treatments for HIV infection improved, HIV-infected individuals face continued risks for esophageal and stomach carcinomas.
http://linkinghub.elsevier.com/retrieve/pii/S0016508512009638?showall=true