A New Role for PHD in Chemotherapy
Menée à l'aide d'un modèle murin, cette étude suggère que l'inhibition de l'enzyme PHD2 permet d'augmenter l'efficacité d'une chimiothérapie et de réduire la toxicité associée
Enhancing therapeutic activity against cancer cells and minimizing toxic effects on normal cells are critical elements in chemotherapy. In this issue of Cancer Cell, Leite de Oliveira and colleagues reveal a previously unrecognized role of a prolyl hydroxylase domain in promoting drug delivery to tumors and reducing toxicity in normal organs.
Cancer cell , commentaire, 2011