Clinical trial data as a public good
Cet article plaide pour un libre accès aux données de tous les essais cliniques, que leurs résultats aient fait l'objet d'une publication ou non
Knowledge of the benefits and risks of prescription drugs is based mainly on published reports of clinical trials, yet the medical literature may present an incomplete and potentially biased sample of clinical trials. Trials with positive results generally are published more frequently than studies that conclude that a new drug poses greater risks or is no more effective than standard therapy or a placebo. Furthermore, some articles may distort trial findings by omitting important data or by modifying prespecified outcome measures. Lack of access to detailed information about clinical trials can undermine the integrity of medical knowledge.
JAMA: The Journal of the American Medical Association , résumé, 2011