Ready, Set, Go: The EGF Receptor at the Pancreatic Cancer Starting Line
Menées sur des modèles murins, ces deux études mettent en évidence le rôle essentiel joué par la signalisation EGFR dans les cancers du pancréas associés à des mutations activant l'expression du gène KRAS
Acinar-to-ductal metaplasia (ADM) results from pancreatic injury or KRAS activation, and is an early step in pancreatic cancer progression. In this issue of Cancer Cell, Ardito and colleagues and Navas and colleagues demonstrate that ADM- and KRAS-driven pancreatic cancer require EGFR signaling, revealing a mechanism for developmental reprogramming that primes tumorigenesis.
Cancer cell , commentaire, 2011