Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
Menée sur 823 patients atteints d'un cancer du sein et 2 795 témoins, cette étude d'association sur le génome entier identifie un polymorphisme à simple nucléotide du gène RAD51B en association avec le risque de cancer du sein chez l'homme
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10−13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10−15; OR = 1.50).
Nature Genetics 2012