Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx
Menée sur 81 patients atteints d'un carcinome épidermoïde du larynx ou de l'hypopharynx de stade loco-régional avancé, cette étude évalue, du point de vue du contrôle de la maladie et de la survie globale, la valeur pronostique du volume tumoral métabolique mesuré au moyen d'une tomographie numérique par émission de positrons à base de fluorodésoxyglucose (18F)
Background Metabolic tumor volume (MTV) of 18F-FDG PET/CT is a volumetric measurement of tumor cells with increased 18F-FDG uptake. We evaluated the prognostic value of MTV in patients with locoregionally advanced laryngeal and hypopharyngeal cancer.Patients and methods We evaluated 81 patients with advanced-stage squamous cell carcinoma of the laryngohypopharynx who underwent 18F-FDG PET/CT between January 2004 and September 2009. Clinicopathologic factors and MTV were analyzed for their association with locoregional control (LRC) and overall survival (OS).Results The 3-year LRC and OS for all patients were 70.9 and 78.7%, respectively, with a median follow-up of 40.4 months (range 24.5–90.1). In univariate analyses, MTV, primary site, and primary treatment strategy were associated with both LRC and OS (P < 0.05). On multivariate analysis, MTV was an independent prognostic factor for both LRC [P = 0.018; HR = 3.141, 95% confidence interval (CI) = 1.175–8.399] and OS (P = 0.008; HR = 3.758, 95% CI = 1.415–9.982). Primary site was also a significant prognostic factor for LRC (P = 0.047).Conclusion Pretreatment MTV is an independent prognostic factor in patients with locoregionally advanced squamous cell carcinoma of the larynx and hypopharynx.
Annals of Oncology , résumé, 2012