Cyclin D1 G870A Polymorphism is a Risk Factor for Esophageal Cancer Among Asians
A partir d'une revue systématique de la littérature publiée jusqu'en février 2012 (8 études cas-témoins), cette méta-analyse montre que le polymorphisme G870A du gène de la cycline D1 est associé au risque de carcinome de l'œsophage chez les personnes d'origine asiatique (1 252 cas, 1 764 témoins)
Investigations concerning the association of Cyclin D1 (CCND1) G870A polymorphism with esophageal cancer risk have generated conflicting results. Thus, meta-analyses were conducted. The overall data suggest that CCND1 G870A variation might have an association with increased esophageal cancer susceptibility. In subgroup analyses on ethnicity, homozygous AA alleles might elevate esophageal cancer risk among Asians but not Caucasians. In subgroup analysis on histological types, no association was found in either the adenocarcinoma or the squamous cell carcinoma subgroup. Collectively, results suggest that CCND1 G870A polymorphism might be a low-penetrant risk factor for esophageal carcinoma, particularly among Asians.
Cancer Investigation 2012