Genetic Polymorphism of PRKCDBP is Associated With an Increased Risk of Endometrial Cancer
A partir d'échantillons tumoraux et d'échantillons de tissu sain prélevés respectivement sur 147 patientes atteintes d'un cancer de l'endomètre et sur 191 témoins, cette étude coréenne montre qu'un polymorphisme du gène PRKCDBP, un probable suppresseur de tumeur localisé sur le chromosome 11p15.4, est associé à un risque accru de développer la maladie
PRKCDBP is a putative tumor suppressor located at 11p15.4, where frequent genomic loss has been observed in human cancers. We explored the possible association between an intra-exonic single nucleotide polymorphism (SNP), rs1051992, that results in a Leu to Pro substitution, and risk for endometrial carcinogenesis. We assessed the genotype of rs1051992 in endometrial cancer tissues from 147 patients and normal endometrial tissue from 191 healthy individuals by restriction endonuclease PvuII-based genotyping. Allele frequencies in the cancer specimens were compared with those in the healthy controls. We also evaluated the association between polymorphisms at this locus and histopathological features of endometrial cancer.