Assessment of the Effects of Severe Obesity and Lifestyle Risk Factors On Stage of Endometrial Cancer
A partir d'enquêtes menées auprès de 177 patientes atteintes d'un cancer de l'endomètre, cette étude analyse les effets d'une obésité sévère et de facteurs de risque liés au mode de vie sur le stade de la maladie au diagnostic
Background:Lifestyle risk factors, including obesity, have been associated with increased risk of endometrial cancer (EC). Women with higher obesity levels tend to have less aggressive EC disease stage and histology. This study further investigated associations between non-modifiable risk factors, such as age, race and grade, and modifiable lifestyle factors, such as diet and physical activity expenditure, in relation to severe obesity and late versus early EC stage at diagnosis. Methods:Demographic, anthropometric and lifestyle surveys were administered to 177 women with histologically confirmed EC. Logistic regression analyses assessed the relationship between obesity and other risk factors on EC stage at diagnosis. Results:In multivariate models, BMI<35 was not significantly associated with late EC stage at diagnosis (OR=1.67, p=0.219) when adjusting for grade and age. Grade was significantly associated with EC stage when controlling for BMI and age (OR=8.48, p=.000). Women over age 60 had a 4-fold increased risk of diagnosis at late versus early EC stage when adjusting for other risk factors. Age had a confounding effect on the obesity-EC stage association. Conclusions:Our results corroborate those of past studies showing that BMI is not an independent risk factor for EC stage and that age may have confounded the obesity-EC stage association. Due to mixed results and implications for treatment outcomes, however, further research examining these variables is warranted. Impact: Our results provide further insight into the obesity EC-stage association, especially the confounding effect of age. Future studies should examine modifiable lifestyle factors in larger and more diverse populations.