Primary systemic treatment of breast-cancer brain metastases
Mené sur 45 patientes atteintes d'un cancer du sein HER2+ avec métastases cérébrales, cet essai de phase II évalue, du point de vue du pourcentage de patientes avec une réponse objective, le lapatinib en combinaison avec la capécitabine en traitement de première ligne
A decade ago, an apparent increase in the incidence of brain metastases was reported in patients with HER2-positive metastatic breast cancer receiving HER2-targeted antibody trastuzumab. In the following years, growing awareness of breast-cancer brain metastases has pushed this once obscure field of research to the centre of scientific interest.
Treatment of brain metastases in patients with breast cancer has long been a domain of local therapy, with whole brain radiotherapy (WBRT) being the standard of care in patients with multiple CNS lesions. Outcome with WBRT alone, however, is poor and causes much late toxicity...
The Lancet Oncology , commentaire en libre accès, 2011