Realizing the Clinical Potential of Cancer Nanotechnology by Minimizing Toxicologic and Targeted Delivery Concerns
Cet article passe en revue les limites liées à la toxicité des nanoparticules envisagées pour le traitement des cancers et analyse les stratégies permettant de contourner les divers obstacles
Nanotechnology has the potential to make smart drugs that would be capable of targeting cancer but not normal cells and to load combinations of cooperating agents into a single nanosized particle to more effectively treat this disease. However, to realize the full potential of this technology, the negative aspects associated with these nanoparticles need to be overcome. This review discusses concerns in the field limiting realization of the full clinical potential of this technology, which are toxicity and targeted delivery. Strategies to overcome these hurdles are also reviewed, which could lead to attainment of the full clinical potential of this exciting technology. Cancer Res; 72(22); 1–6. ©2012 AACR.
Cancer Research , résumé, 2012