Future directions in cancer prevention
Cet article passe en revue les futurs axes de recherche en matière de prévention des cancers, notamment les approches moléculaires permettant d'identifier les voies associées aux phases d'initiation et de développement de la maladie ainsi que les approches immunologiques pouvant inhiber la carcinogenèse
Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and medical approaches to cancer prevention. These include selective oestrogen receptor modulators and aromatase inhibitors for breast cancer, the 5-
α-reductase inhibitors finasteride and dutasteride for prostate cancer, and the development of vaccines for viruses that are associated with specific cancers. Future directions include genetic, proteomic and other molecular approaches for identifying pathways that are associated with cancer initiation and development, as well as refining the search for immunologically modifiable causes of cancer.
Nature Reviews Cancer , résumé, 2011