Long term improved quality of life by a 2-week group physical and educational intervention shortly after breast cancer chemotherapy completion. Results of the ‘Programme of Accompanying women after breast Cancer treatment completion in Thermal resorts’ (PACThe) randomised clinical trial of 251 patients
A partir des données d'un essai randomisé multicentrique incluant 251 participantes, cette étude analyse l'efficacité d'une intervention, à base d'activité physique, d'éducation à la santé et de physiothérapie, destinée à améliorer la qualité de vie à long terme de survivantes d'un cancer du sein après la complétion de leur chimiothérapie
Quality of life (QoL) after breast cancer is nowadays a major challenge. Complementary interventions are necessary because of frequent depression symptoms after treatment and also to favour return to activity. Besides, radio-chemotherapy has side-effects like weight gain and fatigue. Several strategies including group behavioural-educational interventions, physical training and/or dietary education, have been tested to answer these difficulties with moderate success in the long run. Two hundred and fifty-one non-metastatic patients were accrued after chemotherapy in a prospective randomised multicenter trial between 2008 and 2010, testing a 2-week intervention in SPA centres. Intervention comprised group physical training, dietary education and physiotherapy. Selected patients were in complete remission. QoL was evaluated with SF36 questionnaire, anxiety and depression with the hospital anxiety and depression (HAD) one. Anthropometric measures and QoL evaluations were obtained before randomisation and every 6months during 3years. Two hundred and twenty patients were evaluable at 1year. Intervention increased SF36 score by 9.5 points (p=0.000006), 4.6 (p=0.032) and 6.2 (p=0.028) respectively at 6, 12 and 24months. Effect size (ES) was 0.63 [0.37; 0.90], 0.29 [0.03; 0.55] and 0.41 [0.04; 0.78]. Anxiety score was shortly minored by intervention (6-month ES=−0.24 [−0.42; −0.05]) and depression score more durably: ES=−0.45 [−0.72; −0.18], −0.34 [−061; −0.08], and −0.26 [−0.63; 0.11] at 6, 12 and 24months. This 2-week group intervention seemed to durably influence QoL of breast cancer patients treated by chemotherapy. Differences, smaller at 12months than at six, suggest that a second but shorter intervention could help maintain the 6-month benefits.
http://linkinghub.elsevier.com/retrieve/pii/S0959804912010301?showall=true