The Role of Telomeres in Stem Cells and Cancer
Cet article passe en revue les travaux récents sur le rôle de la télomérase dans les cellules souches et la cancérogenèse
Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
Cell 2013