Cancer Prevention by Tocopherols and Tea Polyphenols
Cet article passe en revue les études récentes concernant l'effet chimiopréventif des polyphénols du thé vert et des tocophérols sur la carcinogenèse du côlon, du poumon, du sein et de la prostate
Tocopherols (vitamin E) and tea polyphenols have been reported to have cancer preventive activities. Large-scale human trials with high doses of alpha-tocopherol, however, have produced disappointing results. This review presents data showing that - and -tocopherols inhibit colon, lung, mammary and prostate carcinogenesis in animal models, whereas -tocopherol is ineffective in animal and human studies. Possible mechanisms of action are discussed. A broad cancer preventive activity of green tea polyphenols has been demonstrated in animal models, and many mechanisms have been proposed. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated.
http://www.sciencedirect.com/science/article/pii/S0304383513000979