Statin therapy is not associated with prostate cancer recurrence among patients who underwent radiation therapy
Menée sur une cohorte de 774 patients atteints d'un cancer de la prostate traité par radiothérapie (durée de suivi : 5 ans), cette étude ne montre pas d'association entre l'utilisation de statines après le traitement et une réduction du risque de récidive
We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California health plan was followed for 5 years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio=0.99 (0.70-1.39), 0.87 (0.62-1.22) and 0.78 (0.55-1.09), respectively] in multivariable Cox models. No clear dose-response relationship was observed for average daily statin dose or duration of statin use. Our findings do not support a preventive benefit of statins in prostate cancer recurrence after radiotherapy.
http://www.sciencedirect.com/science/article/pii/S0304383513001298