Role of MYCN in retinoblastoma
A partir d'échantillons tumoraux prélevés sur 1 068 patients atteints d'un rétinoblastome unilatéral non héréditaire, cette étude analyse les caractéristiques génomiques, histologiques et cliniques des tumeurs ne présentant pas de mutations du gène RB1 (29 tumeurs identifiées)
The discovery of proto-oncogenes transformed our insight into mechanisms of cancer. Subsequently, identification of the retinoblastoma gene ( RB1 ) heralded the notion that malignant disease has a hereditary basis, by showing that both germinal and somatic acquisition of mutations in a tumour-suppressor gene causes tumorigenesis. Indeed, analysis of the latency of tumour onset had predicted—even before the culprit gene was found—that retinoblastoma would arise either through a single hit in the re ...
The Lancet Oncology , commentaire, 2012