Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study
Menée en Suède sur une cohorte de 44 613 hommes âgés de 45 à 79 ans (durée de suivi : 12 ans), cette étude évalue l'association entre la consommation de café et le risque de cancer localisé, avancé ou fatal de la prostate (respectivement 2 368, 918 et 515 cas)
Background The epidemiological evidence on possible relationships between coffee consumption and prostate cancer (PCa) risk by subtype of the disease (localized, advanced) and fatal PCa risk is limited. Materials and methods A population-based cohort of 44 613 Swedish men aged 45–79 years was followed up from January 1998 through December 2010 for incidence of localized (n = 2368), advanced (n = 918) and fatal (n = 515) PCa. We assessed the associations between coffee consumption and localized, advanced and fatal PCa risk using competing-risk regressions. We examined possible effect modification by body mass index (BMI). Results For localized PCa, each one cup increase in daily coffee consumption was associated with a 3% reduced risk [sub-hazard ratio (SHR) = 0.97, 95% confidence interval (CI) = 0.95–0.99]. For advanced and fatal PCa, we found a non-significant inverse association; each one cup increase was associated with a 2% reduced risk of advanced [SHR (95% CI) = 0.98 (0.95–1.02)] and fatal PCa [SHR (95% CI) = 0.98 (0.93–1.03)]. We observed evidence of effect modification by BMI for localized PCa (Pinteraction = 0.03); the inverse association was stronger among overweight and obese men (BMI ≥ 25 kg/m2) compared with normal-weight men (BMI < 25 kg/m2). Conclusions We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.