An Ounce of Prevention Is Better Than a Pound of Cure: A Patient-Centered Approach to Hepatocellular Carcinoma
A partir des données de l'assurance maladie taïwanaise portant sur 260 864 patients infectés par le virus de l'hépatite C, cette étude analyse l'association entre l'utilisation de statines et le risque de carcinome hépatocellulaire (1 378 cas parmi les 35 023 utilisateurs de statines ; 26 505 cas parmi les 225 841 témoins)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Though it is less commonly seen in the United States, age-adjusted incidence rates have tripled here over the last three decades, and overall survival remains poor for those with advanced disease. Host factors, including viral hepatitis, metabolic syndrome, alcohol use, and genetic disorders, contribute to HCC pathogenesis, both singly and in combination. HCC is notable for havingparticularlyvariedetiologiesindifferentpopulations.Hepatitis B vaccination programs have begun to show dramatic decreases in HCC incidence, but for those with other underlying risk factors, primary prevention efforts have been disappointing...
Journal of Clinical Oncology , éditorial en libre accès, 2013