A prospective study of plasma inflammatory markers and risk of colorectal cancer in men
Menée sur 274 patients atteints d'un cancer colorectal et sur 532 témoins, cette étude prospective évalue l'association entre le niveau plasmatique de marqueurs de l'inflammation (protéine C réactive, interleukine-6, récepteur soluble sTNFR-2) et le risque de développer la maladie
Background : Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
Methods : We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40; Ptrend=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05; Ptrend=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (Pinteraction=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Conclusion : Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.
British Journal of Cancer , résumé, 2012