Prostate cancer susceptibility genes on 8p21-23 in a Dutch population
Menée sur 292 patients atteints d'un cancer de la prostate et sur 278 témoins, cette étude néerlandaise évalue l'association entre des marqueurs microsatellitaires de la région chromosomique
Background : Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21–23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and narrow down the location of candidate prostate cancer genes. Methods : 292 cases and 278 controls were selected from the Netherlands Cohort Study (NLCS). The following MSs were used in the analyses: D8S136, D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. Associations were evaluated using a
χ2 test and logistic regression. We checked for any effects on the association by tumour stage. Results
:
Associations that were found confirmed previous research that pointed to the 8p21
–23 region. Two MSs: D8S136 (odds ratio (OR), 0.69; P=4.00 × 10−28), and D8S520 (OR, 0.80; P=3.37 × 10−11), were consistently and strongly related with prostate cancer. Genotype analysis showed an additive effect for D8S136 (P-trend=6.22 × 10−03) and D8S520 (P-trend=2.62 × 10−22), suggesting an increased risk for people with a short number of repeats on both alleles at those markers. Conclusions : This study provides strong evidence that the 8p21–23 region is likely to harbour prostate cancer genes.