A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence
A partir de questionnaires auprès d'une cohorte de 111 356 participantes âgées de 50 à 71 ans, cette étude prospective évalue l'association entre la consommation de poisson, de viande ou de substances carcinogènes générées par la cuisson et le risque de cancer de l'endomètre (1 486 cas)
Background : There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent. Methods : We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results : We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77–1.08), white (0.98, 0.83–1.17), processed meats (1.02, 0.86–1.21) and fish (1.10, 95% CI 0.93–1.29). We also found no associations between meat mutagen intakes and endometrial cancer. Conclusion : Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer.