Physical activity and risk of lymphoma: a meta-analysis
A partir d'une revue de la littérature publiée jusqu'en janvier 2013 (7 études cas-témoins et 5 études de cohorte), cette méta-analyse évalue l'association entre le niveau d'activité physique auto-rapporté et le risque de lymphome
Physical activity (PA) has a protective effect on some types of cancer. The aim of the present meta-analysis was to explore the literature on the association between PA and risk of lymphoma. A meta-analysis was conducted for cohort and case-control studies examining the association between self-reported PA and risk of lymphoma. Depending on statistical heterogeneity, a random or fixed effects model was used to estimate the summary odds ratio and corresponding 95% confidence interval. Seven case-control studies and 5 cohort studies were included. When data from both study designs were combined, no significant influence of PA on risk of lymphoma was found (pooled OR = 0.90, 95% CI: 0.79 - 1.02, p = 0.10). Subgroup analysis revealed a significant protective influence of PA on risk of lymphoma in case-control studies (pooled OR = 0.81, 95% CI: 0.68-0.96, p = 0.02). In contrast, cohort studies, which have a higher level of evidence than case-control studies, confirm the results of the primary meta-analysis (pooled OR = 1.02, 95% CI: 0.88-1.19, p = 0.76). A subsequent subgroup analysis found no significant differences between results for Hodgkin's lymphoma and non-Hodgkin's lymphoma (Chi² = 0.16, p = 0.69), nor between results for recreational and occupational activities (Chi² = 1.01, p = 0.31). Epidemiological research indicates no significant influence of PA on risk of lymphoma. Future research should examine the association between sedentary behavior and risk of lymphoma and investigate the dose-response and timing effect of PA on risk of lymphoma.