Tubal ligation in relation to menopausal symptoms and breast cancer risk
A partir des données de la cohorte "Sister Study" incluant 50 884 femmes, cette étude analyse l'association entre une ligature des trompes, des symptômes de la ménopause et le risque de cancer du sein
Background: Local inflammation after tubal ligation may affect ovarian function and breast cancer risk. Methods: We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50 884 women). Results: Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06–1.12) but not menopausal age (HR 0.99; 95% CI: 0.96–1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85–1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70–1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy. Conclusion: Tubal ligation does not influence overall breast cancer risk