Breast Cancer Bone Metastases: It s All about the Neighborhood
Menée in vitro et in vivo, cette étude met en évidence des mécanismes par lesquels, dans le micro-environnement d'une tumeur primitive du sein triplement négative, des fibroblastes associés au cancer favorisent le développement de métastases osseuses
In order to establish themselves in distal sites, metastatic cancer cells need to acquire organ-specific traits. Zhang et al. provide evidence in breast cancer that a tumor cell's acquisition of properties for successful bone metastasis is influenced by signals from the stroma of the primary tumor.
Cell , commentaire, 2012