Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia
Menée sur 278 cas et 358 témoins, cette étude en population britannique évalue l'association entre l'utilisation d'hormones exogènes, l'histoire reproductive et le risque de leucémie myéloïde chez l'adulte
Background: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. Methods: In this population-based case–control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype. Results: We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32–0.96). Hormone replacement therapy and reproductive factors were not associated with risk. Conclusion: Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.