Risk of differentiated thyroid carcinoma and polymorphisms within the susceptibility cancer region 8q24
Menée en Italie auprès de 1 250 cas et de 1 250 témoins, cette étude évalue l'association entre six polymorphismes à simple nucléotide situés sur la région 8q24 et le risque de cancer thyroïdien différencié
Background: Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, and it was also defined as the "susceptibility cancer region". Thus, it could be hypothesized that genetic variants within this region could play a role in the risk of differentiated thyroid carcinoma (DTC). Methods: Six SNPs within 8q24 were analysed, previously associated with the risk of cancer (i.e. rs6983267, rs1447295, rs10808556, rs7000448, rs13254738, and rs13281615) in a population of 1250 patients affected by DTC and 1250 controls from the Centre and Southern Italy. Results: A strong association between smoking habit and risk of DTC was found (OR=1.63; 95% CI 1.39-1.91; P<10-6). The polymorphisms rs10808556 and rs1447295 showed an association with the risk of DTC (the strongest were the heterozygotes with OR=1.38, 95% CI 1.13-1.68, and OR=1.35, 95% CI 1.02-1.78, respectively), but, overall, they were unable to reach the statistically significance threshold following Bonferroni's correction. Conclusions: Present study suggested a limited involvement of polymorphisms within 8q24 region in relation to the risk of DTC in Centre and Southern Italians. Impact: The exclusion of a relationship between DTC and 8q24 among Italians further highlights the tissue-specificity of this chromosomal segment in relation to human cancer and stresses the importance of other population-specific cofactors.