Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma
Menée initialement sur plusieurs cohortes de patients atteints d'un lymphome hodgkinien (1 465 au total) et de témoins (6 417 au total), puis sur une cohorte complémentaire de 2 024 cas et 1 853 témoins, cette méta-analyse d'études d'association sur le génome entier identifie deux nouveaux loci de susceptibilité à la maladie sur les régions chromosomiques 3p24.1 et 6q23.3
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.