Interaction of Benzo(a)pyrene with Other Risk Factors in Hepatocellular Carcinoma: A Case–Control study in Xiamen, China
Menée en Chine auprès de 345 cas et de 961 témoins, cette étude évalue les interactions entre une exposition environnementale au benzo[a]pyrène (un hydrocarbure aromatique polycyclique), une exposition à d'autres facteurs de risque et le risque de carcinome hépatocellulaire
Purpose : Large epidemiological studies about the relationship between benzo(a)pyrene [B(a)P] and hepatocellular carcinoma (HCC) have been limited. B(a)P diol epoxide (BPDE) is a highly reactive metabolite of B(a)P that binds covalently to form DNA adducts. We evaluated the interaction between B(a)P exposure with other risk factors in HCC, in a case-control study of 345 HCC and 961 healthy controls. Methods : Concentration of BPDE–DNA adducts in blood was determined by ELISA. The interaction between BPDE-DNA adducts and other risk factors on HCC were evaluated by multivariate logistic regression analysis. Results : Mean concentration of BPDE–DNA adducts in blood of cases was significantly higher than that of controls. The risk of HCC increased with elevated concentration of BPDE-DNA adducts(x2 =203.57, Ptrend <0.001), and the OR was 7.44 (95%CI:5.29-10.45) for the first vs fourth quartile of adduct levels. The relative excess risk due to interaction between BPDE–DNA adducts and HBsAg and drinking was 34.71 and 54.92, and attributable proportion due to interaction was 41.53 and 75.59%, respectively. Conclusion : The high level of BPDE–DNA adducts in blood is associated with HCC and that environmental exposure to B(a)P may increase the risk of HCC, especially among drinkers and populations with HBV infection.