Killing Tumors by Keeping Ras and PI32 Kinase Apart
Menée à l'aide d'un modèle murin, cette étude met en évidence des mécanismes suggérant l'intérêt d'inhiber l'interaction entre la sous-unité p110
Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110
α interaction for full activation of PI3K and tumor maintenance.
Cancer cell , commentaire, 2012