The club cell and its protein, CC16: time to shine
Menée à partir d'échantillons sériques cryopréservés après prélèvement sur 1 086 patients âgés de 21 à 70 ans, cette étude évalue l'association entre la concentration en protéines des cellules de Clara (protéines épithéliales produites par le tissu pulmonaire) et le risque de décès par cancer
Club cell (formerly Clara cell) protein or CC16 (also known as CC10, club cell secretory protein, and uteroglobin) is a member of the secretoglobin family of small disulphide bridge dimeric proteins. It is secreted by non-ciliated epithelial club cells in the large and small airways and is the most abundant protein present in normal airway secretions. Several lines of evidence suggest that CC16 has an important role in lung defence in experimental animals...
The Lancet Respiratory Medicine , commentaire, 2012