Circulating tumour cells: telling the truth about metastasis
Menée à partir des données de 20 études européennes portant sur 1 944 patientes atteintes d'un cancer métastatique du sein, cette étude évalue l'association entre le nombre de cellules tumorales circulantes et la survie des patientes
Medical management of metastatic breast cancer is typically palliative. Several clinical and molecular variables must be considered to select the most effective and least toxic treatment. However, treatment selection is difficult because of the intrinsic clinical, phenotypic, and molecular heterogeneity that causes resistance to existing treatments and is believed to be related to a subpopulation of cancer cells with characteristics of progenitors or cancer stem cells. 2 Cancer stem cells are capa...
The Lancet Oncology , commentaire, 2013