Prevalence of HIV infection among U.S. Hodgkin lymphoma cases
A partir des données de 14 registres américains des cancers portant sur la période 2000-2010, cette étude analyse la prévalence d'une infection par le VIH dans les cas de lymphomes hodgkiniens
Background: Hodgkin Lymphoma (HL) is uncommon in the U.S. general population; however, HL risk is elevated in people with human immunodeficiency virus (HIV) infection. Thus, despite the low HIV prevalence in the U.S, the HIV epidemic may have contributed substantially to the general population burden of HL. Methods: We used data from 14 U.S. cancer registries in the Surveillance, Epidemiology and End Results Program that recorded HIV status of HL cases at diagnosis during 2000-2010. We computed the HIV prevalence in HL cases by demographic and tumor characteristics, the proportion of deaths among HL cases due to HIV, and 5-year mortality by HIV status. Results: Of 22,355 HL cases, 848 (3.79%) were HIV-infected at diagnosis. HIV prevalence in HL cases was greater among males than females (6.0 vs. 1.2%). Among males, HIV prevalence was greatest among 40-59 year-olds (14.2%), non-Hispanic blacks (16.9%), Hispanics (9.9%) and among cases of lymphocyte-depleted (15.1%) and mixed cellularity HL (10.5%). Eight percent of male and 1.5% of female HL cases died from HIV. Five-year mortality was two-fold higher in HIV-infected HL cases (36.9 vs. 17.5%). Conclusions: In the U.S., a substantial proportion of lymphocyte-depleted and mixed cellularity HL cases and HL cases among non-Hispanic black, Hispanic and middle-aged men are HIV-infected. Additionally, HIV is an important cause of death among HL cases. Impact: Clinicians should be aware of the high prevalence of HIV in certain subgroups of HL patients and routine HIV testing should be recommended for all patients presenting with HL.