Anti-PD1 antibody: a new approach to treatment of lymphomas
Mené sur 32 patients atteints d'un lymphome folliculaire récidivant, cet essai de phase II évalue l'efficacité, du point de vue du pourcentage de patients avec réponse objective, et la toxicité du pidilizumab, un anticorps monoclonal anti PD1, en combinaison avec le rituximab
Immunomodulation of the T-cell response can be mediated by many mechanisms including soluble factors such as IL-10 or TGF
β, immunoregulatory cell subsets such as regulatory T cells or follicular helper T cells, and surface receptors such as PD1 (programmed cell death , also known as PDCD1), LAG3, CD244, TIM3 (also known as HAVCR2), CTLA4, or CD160. PD1, a member of the B7 receptor family, is engaged by two ligands (PD-L1 [also known as CD274 ] and PD-L2 [also known as PDCD1LG2 ] ) that are expresse ...
The Lancet Oncology , commentaire, 2012