Nomogram to determine individualized estimates of screen-detected prostate cancer overdiagnosis
Cet article évalue la performance d'un nomogramme, développé à l'aide d'un modèle de microsimulation numérique, pour prédire le risque individuel de surdiagnostic de cancer de la prostate à partir de l'âge du patient, du niveau sérique du PSA ou du score de Gleason au diagnostic
Using a nomogram that incorporates age, Gleason score, and prostate-specific antigen (PSA) level at diagnosis, individual risks that a screen-detected prostate cancer has been overdiagnosed can be estimated, according to a new study published January 6 in the Journal of the National Cancer Institute.
The authors used a standard definition of overdiagnosis to refer to a cancer that would not have become symptomatic or clinically identifiable if it had not been detected by screening. Overdiagnosed cancers do not pose a risk to the patient and do not require treatment, which is associated with significant risks of impotence and incontinence. Previous studies have estimated …
Journal of the National Cancer Institute , éditorial en libre accès, 2014