Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
A partir de bases de données d'expression de gènes, cette étude montre qu'il existe, d'un point de vue moléculaire et clinique, au moins deux sous-types distincts de cancers de la vessie de haut grade et suggère l'intérêt de mesurer l'expression du gène BASE47 pour prédire la réponse thérapeutique
We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-grade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed “luminal” and “basal-like,” which have characteristics of different stages of urothelial differentiation, reflect the luminal and basal-like molecular subtypes of breast cancer, and have clinically meaningful differences in outcome. A gene set predictor, bladder cancer analysis of subtypes by gene expression (BASE47) was defined by prediction analysis of microarrays (PAM) and accurately classifies the subtypes. Our data demonstrate that there are at least two molecularly and clinically distinct subtypes of high-grade bladder cancer and validate the BASE47 as a subtype predictor. Future studies exploring the predictive value of the BASE47 subtypes for standard of care bladder cancer therapies, as well as novel subtype-specific therapies, will be of interest.
Proceedings of the National Academy of Sciences , résumé, 2014