The prenatal origins of cancer
Cet article passe en revue les travaux récents sur la théorie selon laquelle des cellules embryonnaires seraient à l'origine de certains cancers pédiatriques
The concept that some childhood malignancies arise from postnatally persistent embryonal cells has a long history. Recent research has strengthened the links between driver mutations and embryonal and early postnatal development. This evidence, coupled with much greater detail on the cell of origin and the initial steps in embryonal cancer initiation, has identified important therapeutic targets and provided renewed interest in strategies for the early detection and prevention of childhood cancer.
Nature Reviews Cancer , résumé, 2013