Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies
Menée à partir des données de 4 études japonaises incluant au total 191 232 participants (durée de suivi : 2 094 428 personnes-années), cette méta-analyse évalue l'association entre la consommation de légumes ou de fruits et le risque de cancer de l'estomac
Background : Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods : In an analysis of original data from 4 population-based prospective cohort studies encompassing 191,232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results : During 2,094,428 person-years of follow-up, 2,995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend=0.13) among men and 0.83 (0.67-1.03; P for trend=0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend=0.02) among men. Conclusion : This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.