Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in apcmin/+ mic
Menée à l'aide d'un modèle murin de polypose intestinale, cette étude montre qu'une alimentation riche en huile d'olive et en acides gras oméga-3 inhibe la prolifération et la croissance des polypes en agissant sur les processus impliqués dans l'apoptose
The promotion and progression of carcinogenesis are susceptible to nutritional interventions aimed at counteracting cancer development. Lipid metabolism is essential in the onset and progression of tumours as well as for cancer cell survival. In the present study we tested the effects of diets enriched with natural compounds, such as olive oil and salmon oil, in mice that spontaneously develop intestinal polyps (ApcMin/+ mice). For this purpose we evaluated polyp number and volume, intestinal mucosa proliferation/apoptosis, oestrogen receptors (ERs) expression, fatty acid synthase (FAS) and 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase gene expression and enzymatic activity. As compared to the standard diet, the salmon oil-enriched diet, containing a high percentage of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and, to a lesser extent, olive oil-enriched diet reduced polyp number and volume through a reduction of proliferation and a marked pro-apoptotic effect. These biological effects were mediated by an inhibition of FAS and HMGCoA reductase gene expression and activity and an increase of ERβ/ERα ratio. Our findings suggest that a proper dietary lifestyle could contribute to primary cancer prevention.
http://carcin.oxfordjournals.org/content/early/2014/03/13/carcin.bgu068.abstract