Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Menée sur 10 patients atteints d'un cancer de l'œsophage de stade localement avancé (âge : 49-75 ans ; durée médiane de suivi : 14 mois), cette étude rétrospective évalue la faisabilité d'une radiothérapie guidée par l'image et conjuguée à la modulation d’intensité en combinaison avec une chimiothérapie concomitante par 5-fluorouracile
Background : In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed. Methods : A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy). Results : At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications. Conclusions : IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
BMC Cancer 2014