Primary systemic therapy and whole breast irradiation for locally advanced breast cancer. A systematic review
A partir d'une revue systématique de la littérature, cette étude évalue l'efficacité et la toxicité d'un traitement pré-opératoire combinant, de manière séquentielle et/ou concomitante, une chimiothérapie et une radiothérapie du sein entier pour traiter un cancer du sein de stade localement avancé
The current management of locally advanced breast cancer (LABC) is based on tri-modality treatment including chemotherapy, radiotherapy and surgery. The concept of preoperative concurrent or sequential chemoradiation for LABC was initially reported more than a decade ago; however this concept did not gain popularity because of the low benefit/risk ratio and the lack of strong data supporting the concept. The purpose of the current systematic review was to explore the published data about preoperative chemoradiation (sequential and/or concurrent) using whole breast irradiation in terms of toxicity and outcome.
http://www.sciencedirect.com/science/article/pii/S1040842814000687 2014