Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: an overview of the literature
Cet article passe en revue les travaux récents sur les chimiothérapies et les thérapies ciblées pour le traitement de métastases cérébrales chez les patients atteints d'un cancer du sein, d'un cancer du poumon, d'un mélanome ou d'un carcinome à cellules rénales
The frequency of metastatic brain tumors has increased over recent years; the primary tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma. While radiation therapy and surgery remain the mainstay treatment in selected patients, new molecular drugs have been developed for brain metastases. Studies so far report interesting results. This review focuses on systemic cytotoxic drugs and, in particular, on new targeted therapies and their clinically relevant activities in brain metastases from solid tumors in adults.