Peptide-based cancer therapy: Opportunity and challenge
Cet article passe en revue les perspectives offertes par le développement de peptides bioactifs pour le traitement des cancers
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer prevention and treatment. Anticancer peptides face several therapeutic challenges. In this review, we present the sources and mechanisms of anticancer peptides and further discuss modification strategies to improve the anticancer effects of bioactive peptides.
http://www.sciencedirect.com/science/article/pii/S0304383514002572 2014