Selenium and Prostate Cancer Prevention: What next - if anything?
Cet article passe en revue les études concernant les effets chimiopréventifs du sélénium sur le risque de cancer de la prostate
Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold Se status below which improvement will decrease prostate cancer risk but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential. Identification of men most likely to benefit from Se status improvement could have significant public health benefits.