Plasma Cell Neoplasms, Their Precursor States, and Their Prediction of Organ Damage
Menée à partir d'échantillons sériques prélevés avant diagnostic sur 20 patients atteints d'une amyloïdose de type AL et sur 20 témoins en bonne santé, cette étude met en évidence une augmentation du niveau des chaînes légères libres avant le développement de la maladie
In 1845, after testing the urine sent by a Dr Watson across London from a patient with mollities ossium (advanced lytic bone disease), 31-year-old H. Bence Jones linked the unusual urine protein that was later named for him to the patient’s bone disease. In the article that accompanies this editorial, Weiss et al add to our knowledge of the natural history of systemic light chain amyloidosis (AL), a plasma cell neoplasm in which immunoglobulin light chains cause organ disease, by linking the presence of a prediagnostic monoclonal gammopathy to the existence of AL cardiac involvement at diagnosis...
Journal of Clinical Oncology , éditorial en libre accès, 2014