Inside and out: the activities of senescence in cancer
Cet article passe en revue les travaux récents sur le rôle joué par la sénescence cellulaire dans le développement tumoral, la fonction de suppresseur de tumeurs et la réponse thérapeutique
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.
Nature Reviews Cancer , résumé, 2013