Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
Cet article passe en revue les travaux récents sur les mécanismes permettant de rendre compte de l'hétérogénéité temporelle et spatiale des tumeurs
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.